PharmD Signal

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Clinical Specialty Index

131 articles indexed across 16 specialties, each reviewed by a licensed pharmacist before publication.

Showing all 131 articles.Sort: Newest | Oldest
2025 AHA/ACC Multi-Society Hypertension Guideline Redefines Risk and Treatment Thresholds
Hypertension Practice-changing Grade: Moderate

The 2025 AHA/ACC Guideline introduces PREVENT-based CVD risk, new secondary hypertension triggers, and major changes in initial drug therapy for pharmacists managing hypertension.

Dual PD-L1/Galectin-9 CRISPR nanoparticles curb melanoma in mice
Oncology Pharmacy Hypothesis-generating Grade: Very Low

CRISPR-loaded nanoparticles boost immune response against cancer.

Semaglutide 2.4 mg Improves Liver Histology in MASH
Endocrinology / Obesity Practice-changing Grade: Moderate

Semaglutide shows promise in treating metabolic dysfunction-associated steatohepatitis.

2025 ACIP Adult Immunization Schedule Introduces Major Universal Vaccine Expansions
Immunization Practice-changing Grade: Moderate

The 2025 ACIP adult schedule features universal and risk-based expansions for pneumococcal, RSV, and polio vaccines, plus product, schedule, and note updates directly relevant to pharmacists.

Tenecteplase Boosts Late-Window Reperfusion but Not 90-Day Function
Neurology / Neuropharmacology Hypothesis-generating Grade: Low

Tenecteplase enhances late-window stroke reperfusion without added hemorrhage risk.

Finerenone Cuts Albuminuria in Type 1 Diabetes with CKD
Endocrinology / Obesity Hypothesis-generating Grade: Moderate

Semaglutide slashes kidney and heart risks in diabetes with kidney disease.

Clinical pharmacy performance indicators skew to process, lack validation
Clinical Pharmacy Practice Hypothesis-generating Grade: Low

Hospital pharmacy KPIs lack validation and benchmark standards.

KDIGO 2024 Chronic Kidney Disease Guideline: Precision CKD Care for Pharmacists
Chronic Kidney Disease Practice-changing Grade: Moderate

The 2024 KDIGO guideline for CKD introduces new recommendations for screening, diagnosis, risk stratification, pharmacologic intervention, and bone-mineral disorder, with significant implications for pharmacist monitoring roles.

TIMELESS: Late-Window Tenecteplase Fails to Improve Stroke Outcomes
Neurology / Neuropharmacology Confirmatory Grade: High

Tenecteplase fails to outperform placebo in delayed stroke treatment.

2023 ACC/AHA/ACCP/HRS AFib Guideline Overhauls Antithrombotic Management Framework
AFib/Antithrombotics Practice-changing Grade: Moderate

Major changes in stroke risk assessment, anticoagulant preferences, and DOAC over warfarin guidance will alter daily pharmacist management of AFib patients.

Semaglutide Cuts Cardiovascular Events in Obesity Without Diabetes
Endocrinology / Obesity Practice-changing Grade: High

Semaglutide cuts heart risks in obesity without diabetes.

Semaglutide Cuts Symptoms and Weight in Obesity-Related HFpEF
Endocrinology / Obesity Practice-changing Grade: High

Semaglutide enhances function and weight loss in obese heart failure patients.

Key Changes in 2023 AGS Beers Criteria for Inappropriate Medications in Older Adults
Beers Criteria Practice-changing Grade: Moderate

The 2023 AGS Beers Criteria update introduces significant modifications and new recommendations impacting antihyperglycemics, anticoagulants, anticholinergics, and select drug–disease interactions for older adults.

GOLD 2023 COPD Report: Major Revisions from the Global Initiative for COPD
COPD Practice-changing Grade: Moderate

The GOLD 2026 update brings significant changes impacting risk stratification, exacerbation management, biologics, and vaccination in COPD care.

CPIC 2022 Update: CYP2C19 Genotype and Clopidogrel Therapy
Pharmacogenomics Practice-changing Grade: Moderate

The strength of recommendation to avoid clopidogrel in CYP2C19 intermediate metabolizers is elevated to strong, and genotype-guided antiplatelet therapy now formally extends to neurovascular indications.