Hypertension Practice-changing Grade: Moderate
The 2025 AHA/ACC Guideline introduces PREVENT-based CVD risk, new secondary hypertension triggers, and major changes in initial drug therapy for pharmacists managing hypertension.
Oncology Pharmacy Hypothesis-generating Grade: Very Low
CRISPR-loaded nanoparticles boost immune response against cancer.
Endocrinology / Obesity Practice-changing Grade: Moderate
Semaglutide shows promise in treating metabolic dysfunction-associated steatohepatitis.
Immunization Practice-changing Grade: Moderate
The 2025 ACIP adult schedule features universal and risk-based expansions for pneumococcal, RSV, and polio vaccines, plus product, schedule, and note updates directly relevant to pharmacists.
Neurology / Neuropharmacology Hypothesis-generating Grade: Low
Tenecteplase enhances late-window stroke reperfusion without added hemorrhage risk.
Endocrinology / Obesity Hypothesis-generating Grade: Moderate
Semaglutide slashes kidney and heart risks in diabetes with kidney disease.
Clinical Pharmacy Practice Hypothesis-generating Grade: Low
Hospital pharmacy KPIs lack validation and benchmark standards.
Chronic Kidney Disease Practice-changing Grade: Moderate
The 2024 KDIGO guideline for CKD introduces new recommendations for screening, diagnosis, risk stratification, pharmacologic intervention, and bone-mineral disorder, with significant implications for pharmacist monitoring roles.
Neurology / Neuropharmacology Confirmatory Grade: High
Tenecteplase fails to outperform placebo in delayed stroke treatment.
AFib/Antithrombotics Practice-changing Grade: Moderate
Major changes in stroke risk assessment, anticoagulant preferences, and DOAC over warfarin guidance will alter daily pharmacist management of AFib patients.
Endocrinology / Obesity Practice-changing Grade: High
Semaglutide cuts heart risks in obesity without diabetes.
Endocrinology / Obesity Practice-changing Grade: High
Semaglutide enhances function and weight loss in obese heart failure patients.
Beers Criteria Practice-changing Grade: Moderate
The 2023 AGS Beers Criteria update introduces significant modifications and new recommendations impacting antihyperglycemics, anticoagulants, anticholinergics, and select drug–disease interactions for older adults.
COPD Practice-changing Grade: Moderate
The GOLD 2026 update brings significant changes impacting risk stratification, exacerbation management, biologics, and vaccination in COPD care.
Pharmacogenomics Practice-changing Grade: Moderate
The strength of recommendation to avoid clopidogrel in CYP2C19 intermediate metabolizers is elevated to strong, and genotype-guided antiplatelet therapy now formally extends to neurovascular indications.