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Guidelines & Consensus Statements

Practice-Changing Guideline & Consensus Updates

Pharmacist-focused summaries of major society guidelines and consensus statements: structured clinical breakdowns, key changes from previous versions, and what to do differently at the point of care.

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Our most complete guideline and consensus statement breakdowns, free to read in full, no subscription required.

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Traumatic Brain Injury Practice-changingGrade: Moderate

Brain Trauma Foundation 4th Edition Severe TBI Guidelines Reshape Neurocritical Practice

The BTF 4th Edition revises hyperosmolar, seizure, steroid, ICP-threshold, and sedation guidance most relevant to neuro-ICU pharmacists.

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Heart Failure Practice-changingGrade: Moderate

2022 AHA/ACC/HFSA Heart Failure Guideline: Major Revisions to GDMT and Phenotypes

The 2022 AHA/ACC/HFSA guideline redefines heart failure subtypes and updates foundational recommendations for GDMT, SGLT2 inhibitors, and phenotype-directed care.

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Beers Criteria Practice-changingGrade: Moderate

Key Changes in 2023 AGS Beers Criteria for Inappropriate Medications in Older Adults

The 2023 AGS Beers Criteria update introduces significant modifications and new recommendations impacting antihyperglycemics, anticoagulants, anticholinergics, and select drug–disease interactions for older adults.

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Neurology & Neurocritical Care

3
AAN and AHS Release Updated Adult Migraine Prevention Pharmacotherapy Guideline
Guideline Neurology / Neuropharmacology Practice-changing Grade: Moderate

This joint AAN/AHS guideline reorganizes migraine preventive selection around evidence confidence, tolerability, safety, and cost while integrating CGRP-targeted agents into first-line options for both episodic and chronic migraine.

AHA/ASA Releases 2022 Guideline for Management of Spontaneous Intracerebral Hemorrhage
Guideline Hemorrhagic Stroke Practice-changing Grade: High

The guideline introduces significant updates in blood pressure management and anticoagulation reversal strategies for ICH.

Brain Trauma Foundation 4th Edition Severe TBI Guidelines Reshape Neurocritical Practice
🔓 Free Teaser Guideline Traumatic Brain Injury Practice-changing Grade: Moderate

The BTF 4th Edition revises hyperosmolar, seizure, steroid, ICP-threshold, and sedation guidance most relevant to neuro-ICU pharmacists.

Cardiology & Anticoagulation

12
ACC/AHA Introduces Precision Lipidology for ASCVD
Guideline Cardiology / Anticoagulation

Dramatic shift to precision lipidology in ASCVD prevention.

EJHF Consensus Redefines Revascularization Role in Heart Failure With CAD
Consensus Statement Cardiology / Anticoagulation Practice-changing Grade: Low

This European Journal of Heart Failure expert consensus reframes coronary revascularization as secondary to optimized guideline-directed medical therapy in heart failure with coronary artery disease, with direct implications for anticoagulant, antiplatelet, and anti-ischemic medication management.

AHA Scientific Statement on Caffeine and Cardiovascular Disease
Consensus Statement Cardiology / Anticoagulation Confirmatory Grade: Low

This AHA scientific statement synthesizes observational and emerging randomized evidence on caffeine and coffee across cardiovascular risk factors and diseases, giving pharmacists a framework for counseling on moderate consumption.

First Australian Guideline for Pediatric Hypertension Identification and Management
Guideline Pediatric Pharmacy Practice-changing Grade: Low

This inaugural Australian pediatric hypertension guideline, adapted from the AAP 2017 framework, gives pharmacists a unified national reference for BP thresholds, screening timing, and antihypertensive selection in patients under 18 years of age.

EAS Consensus Lowers Age and LDL-C Targets for Pediatric FH
Consensus Statement Guideline: Dyslipidemia Practice-changing Grade: Low

This consensus statement recalibrates diagnostic thresholds, treatment initiation age, and LDL-C goals for children with familial hypercholesterolaemia, expanding the pharmacist's role in early lipid-lowering therapy.

ESC and EACTS Issue Consensus on Antithrombotic Therapy After CABG
Consensus Statement Cardiology / Anticoagulation Inconclusive Grade: Low

This joint ESC/EACTS clinical consensus statement addresses antithrombotic management after coronary artery bypass grafting to reduce graft occlusion and thrombotic complications.

2026 ACC/AHA/Multisociety Dyslipidemia Guideline Reframes Lipid Management and Targets
🔓 Free Teaser Guideline Dyslipidemia Practice-changing Grade: Moderate

The 2026 ACC/AHA/Multisociety guideline introduces lower treatment goals, formal risk equations, and mandates Lp(a) assessment for dyslipidemia pharmacists.

2025 AHA/ACC Multi-Society Hypertension Guideline Redefines Risk and Treatment Thresholds
🔓 Free Teaser Guideline Hypertension Practice-changing Grade: Moderate

The 2025 AHA/ACC Guideline introduces PREVENT-based CVD risk, new secondary hypertension triggers, and major changes in initial drug therapy for pharmacists managing hypertension.

2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline on ACS Management
Guideline Acute Coronary Syndrome Practice-changing Grade: Moderate

Reflects pivotal updates in antiplatelet strategy and secondary prevention for Acute Coronary Syndrome management.

2023 ACC/AHA/ACCP/HRS AFib Guideline Overhauls Antithrombotic Management Framework
🔓 Free Teaser Guideline AFib/Antithrombotics Practice-changing Grade: Moderate

Major changes in stroke risk assessment, anticoagulant preferences, and DOAC over warfarin guidance will alter daily pharmacist management of AFib patients.

2022 AHA/ACC/HFSA Heart Failure Guideline: Major Revisions to GDMT and Phenotypes
🔓 Free Teaser Guideline Heart Failure Practice-changing Grade: Moderate

The 2022 AHA/ACC/HFSA guideline redefines heart failure subtypes and updates foundational recommendations for GDMT, SGLT2 inhibitors, and phenotype-directed care.

CHEST's Second Update on VTE: Guidelines for Antithrombotic Therapy
Guideline VTE/Anticoagulation Practice-changing Grade: High

CHEST provides comprehensive updates emphasizing DOAC use for VTE management without cancer.

Nephrology

2
International Hypertension Guidelines in CKD: ESH, ESC, KDIGO, and AHA/ACC Compared
Guideline Nephrology / Renal Pharmacy Confirmatory Grade: Moderate

This narrative review maps where the four major hypertension guidelines converge and diverge for CKD patients, clarifying practical implications for BP targets, RAS inhibition, diuretic selection, and cardio-renal add-on therapies.

KDIGO 2024 Chronic Kidney Disease Guideline: Precision CKD Care for Pharmacists
Guideline Chronic Kidney Disease Practice-changing Grade: Moderate

The 2024 KDIGO guideline for CKD introduces new recommendations for screening, diagnosis, risk stratification, pharmacologic intervention, and bone-mineral disorder, with significant implications for pharmacist monitoring roles.

Endocrinology & Metabolism

6
SEEP Consensus on Pediatric Type 1 Diabetes in Special Situations
Guideline Pediatric Pharmacy Practice-changing Grade: Low

This Spanish Society of Pediatric Endocrinology consensus operationalizes device-specific and situation-specific T1D management for children across emergency, sick-day, surgical, and radiation contexts.

ADA Obesity Association Releases 2026 Adult Obesity Diagnosis and Staging Standards
Guideline Endocrinology / Obesity Practice-changing Grade: Moderate

The ADA's new Obesity Association standards formalize race- and ethnicity-specific BMI thresholds plus waist-based confirmatory measures, reframing obesity diagnosis around adiposity rather than BMI alone.

AASLD Adds Semaglutide to MASH Practice Guidance With NIT-Based Selection
Guideline Gastroenterology / Hepatology Practice-changing Grade: Moderate

This November 2025 AASLD update operationalizes semaglutide (Wegovy) for F2-F3 MASH, replacing biopsy-driven selection with noninvasive test thresholds and detailing a comprehensive GLP-1 safety-monitoring framework relevant to every dispensing and clinical pharmacist.

ADA Standards of Care: Pharmacologic Treatment of Obesity in Adults
Guideline Obesity / Weight Management Practice-changing Grade: Moderate

The ADA's new Obesity Association guideline reframes obesity pharmacotherapy around treating obesity-related diseases rather than weight targets alone, elevates GLP-1RA and dual GIP/GLP-1RA agents to preferred status across multiple comorbidities, and mandates indefinite continuation to prevent weight recurrence.

2026 ADA Standards of Care in Diabetes Update
🔓 Free Teaser Guideline Diabetes Practice-changing Grade: Moderate

Introduces expanded diabetes screening and diagnostic recommendations across diverse populations for pharmacy practice.

EASL-EASD-EASO Guidelines Redefine MASLD Care With Resmetirom Entry
Guideline Gastroenterology / Hepatology Practice-changing Grade: Moderate

The first joint hepatology, diabetology, and obesity guideline under the new MASLD nomenclature elevates incretin therapies and introduces resmetirom as the first approved MASH-targeted pharmacotherapy.

Pulmonary / Respiratory

5
International Expert Consensus Optimizes Asparaginase and Blinatumomab in Frontline ALL
Consensus Statement Oncology / Supportive Care Confirmatory Grade: Low

This international consensus addresses how to integrate asparaginase with the now-standard frontline blinatumomab backbone, including dosing, therapeutic drug monitoring, and adaptations for resource-limited settings.

AAIITO Expert Consensus Reframes Mild-to-Moderate Asthma Toward Proactive Control
Consensus Statement Pulmonology / Respiratory Confirmatory Grade: Low

An Italian Delphi and RAND/UCLA consensus pushes pharmacists toward proactive, phenotype-informed, ICS-containing regimens rather than symptom-driven reliever use in mild-to-moderate asthma.

GOLD 2026 COPD Strategy: Mepolizumab Enters the Algorithm
Guideline COPD Practice-changing Grade: Moderate

GOLD 2026 adds mepolizumab as a second eosinophil-guided biologic option and refines exacerbation-focused escalation, expanding the pharmacist's role in phenotype-driven COPD care.

GOLD 2023 COPD Report: Major Revisions from the Global Initiative for COPD
🔓 Free Teaser Guideline COPD Practice-changing Grade: Moderate

The GOLD 2026 update brings significant changes impacting risk stratification, exacerbation management, biologics, and vaccination in COPD care.

GINA 2021: Two-Track Asthma Strategy Replaces SABA-Only Reliever Reliance
Guideline Asthma Practice-changing Grade: Moderate

GINA 2021 formalizes ICS-formoterol as the preferred reliever across all adult/adolescent steps and adds new pediatric and Step 5 options.

Infectious Disease & Immunization

11
AASLD/IDSA 2025 Hepatitis B Guideline Shifts From Guidance to Recommendations
Guideline Infectious Disease / Antimicrobials Practice-changing Grade: Low

The first formal AASLD/IDSA HBV guideline (versus prior guidance) tightens antiviral treatment thresholds, adds tenofovir alafenamide for pregnancy, and newly addresses horizontal transmission and expanded liver cancer surveillance.

IDSA Multisociety Position Paper: Hospital Strategies to Improve Sepsis Outcomes
Consensus Statement Infectious Disease / Antimicrobials Practice-changing Grade: Moderate

A new IDSA-led multisociety consensus prioritizes pharmacist-driven levers including beta-lactam-first sequencing, prolonged-infusion defaults, and second-dose timeliness to improve sepsis outcomes beyond bundle compliance.

Prolonged Beta-Lactam Infusions Benefit the Critically Ill
Consensus Statement Infectious Disease / Antimicrobials

Prolonged beta-lactam infusions improve survival in severe illness.

Genetic Testing Prevents Aminoglycoside-Induced Hearing Loss
Guideline Infectious Disease / Antimicrobials

Genetic testing can prevent irreversible hearing loss from antibiotics.

Multisociety Consensus Endorses Beta-Lactam Dose Individualization in Acutely Ill Patients
Consensus Statement Infectious Disease / Antimicrobials Practice-changing Grade: Low

Seven international societies now formally back concentration-guided beta-lactam dosing, positioning pharmacists to lead TDM and model-informed personalized dosing programs.

EuroGuiDerm 2025 Acne Update: Antibiotic Limits, Hormonal Options
Guideline Women's Health Confirmatory Grade: Moderate

This targeted guideline update clarifies when to favor hormonal therapy and spironolactone over prolonged antibiotics in female acne patients, with pregnancy-specific and contraceptive counseling implications for pharmacists.

ECIL-10 Reshapes Febrile Neutropenia Antibiotic Strategy Around Stewardship
Guideline Infectious Disease / Antimicrobials Practice-changing Grade: Moderate

The 10th European Conference on Infections in Leukaemia repositions carbapenem-sparing monotherapy, risk-stratified empirical selection, and neutrophil-count-independent antibiotic discontinuation as the standard for haematology and transplant patients.

2025 ACIP Adult Immunization Schedule Introduces Major Universal Vaccine Expansions
🔓 Free Teaser Guideline Immunization Practice-changing Grade: Moderate

The 2025 ACIP adult schedule features universal and risk-based expansions for pneumococcal, RSV, and polio vaccines, plus product, schedule, and note updates directly relevant to pharmacists.

IDSA/SHEA 2021 Focused Update on Clostridioides difficile Infection Management
🔓 Free Teaser Guideline Clostridioides difficile Infection Practice-changing Grade: High

This guideline prioritizes fidaxomicin over vancomycin and updates on adjunct therapies.

2019 ATS/IDSA Community-Acquired Pneumonia Guideline: Practice-Defining Updates
🔓 Free Teaser Guideline Community-Acquired Pneumonia Practice-changing Grade: Moderate

The 2019 ATS/IDSA CAP guideline introduces major shifts in diagnostic and empiric therapy strategies for adult patients.

2016 ATS/IDSA HAP/VAP Guideline: HCAP Retired, Antibiograms Prioritized
Guideline Hospital-Acquired & Ventilator-Associated Pneumonia Practice-changing Grade: Low

The 2016 ATS/IDSA update reshapes empiric antibiotic selection, de-escalation, and duration of therapy for hospital-acquired and ventilator-associated pneumonia around local resistance data and pharmacokinetic optimization.

Critical Care & Sepsis

1
Surviving Sepsis Campaign 2026 Guidelines Overhaul Adult Sepsis Management
Guideline Critical Care / ICU Practice-changing Grade: Moderate

The SCCM/ESICM 2026 update adds prehospital and MDR-stratified antimicrobial guidance, elevates prolonged beta-lactam infusion to a strong recommendation, and expands biomarker, hemodynamic, and long-term recovery statements directly relevant to ICU pharmacists.

Geriatrics

2
Risks of Psychotropic Use in Alzheimer's Disease
Guideline Geriatrics / Geriatric Pharmacy

Psychotropic polypharmacy poses significant risks in Alzheimer's disease.

Key Changes in 2023 AGS Beers Criteria for Inappropriate Medications in Older Adults
🔓 Free Teaser Guideline Beers Criteria Practice-changing Grade: Moderate

The 2023 AGS Beers Criteria update introduces significant modifications and new recommendations impacting antihyperglycemics, anticoagulants, anticholinergics, and select drug–disease interactions for older adults.

Pharmacogenomics

1
CPIC 2022 Update: CYP2C19 Genotype and Clopidogrel Therapy
Guideline Pharmacogenomics Practice-changing Grade: Moderate

The strength of recommendation to avoid clopidogrel in CYP2C19 intermediate metabolizers is elevated to strong, and genotype-guided antiplatelet therapy now formally extends to neurovascular indications.

Therapeutic Drug Monitoring

2
AGNP 2026 Update Overhauls Therapeutic Drug Monitoring in Neuropsychopharmacology
Guideline Pharmacokinetics / TDM Practice-changing Grade: Low

The AGNP TDM task force delivers a systematically revised, evidence-based set of therapeutic and dose-related reference ranges for 160 neuropsychiatric drugs, plus integrated pharmacogenetic guidance, giving TDM pharmacists new interpretive tools and expanded drug coverage.

Revised Vancomycin Guidelines by ASHP/IDSA/PIDS/SIDP for MRSA: AUC Monitoring Emphasized
Guideline Vancomycin TDM Practice-changing Grade: High

The latest vancomycin guidelines prioritize AUC-guided monitoring over traditional trough levels for MRSA infections.

Other

2
2025 ACR SLE Guideline Prioritizes Hydroxychloroquine and Glucocorticoid Minimization
Guideline Rheumatology / Immunology Practice-changing Grade: Low

The American College of Rheumatology reframes non-renal SLE management around universal hydroxychloroquine, aggressive glucocorticoid tapering, and earlier immunosuppressive escalation.

EULAR 2025 Streamlines Rheumatoid Arthritis DMARD Management to Nine Recommendations
🔓 Free Teaser Guideline Rheumatology / Immunology Confirmatory Grade: Moderate

The 2025 EULAR rheumatoid arthritis recommendations abandon prognostic-factor stratification after methotrexate failure and endorse less frequent laboratory monitoring after early tolerance, both directly relevant to ambulatory pharmacists managing DMARD regimens and adherence.

More Coming Soon

Guidelines and consensus statements currently in the analysis pipeline:

Geriatrics / Geriatric PharmacyNeurology / NeuropharmacologyPediatric PharmacyInfectious Disease / Antimicrobials + 38 more in the queue

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