PharmD Signal

Deep dives, evidence grades, and clinical tools, all in one place.

📚 Clinical Reference

Look It Up Fast, or Read It Properly

Two depths, depending on how much time you have. All of it written for pharmacists who have to act on it, not for a textbook. For multi-study evidence syntheses, see Evidence Rounds.

⚡ Quick-Reference Cards
One printable page. The dose, the target, the conversion, the trap. For mid-shift.
📚 Full Reference Pages
A whole drug class end to end, by specialty. Indications through monitoring.

⚡ Quick-Reference Cards

The number you need mid-shift, on one printable page. Doses, targets, conversions, and the traps, with no preamble. Built for the moment you are already on the phone.

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DOAC Quick Card
Dosing, renal adjustment, reversal, and red flags for the four FDA-approved DOACs, on one printable page.
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Anticoagulant & Antithrombotic Reversal Quick Card
Bedside reversal by agent: warfarin, the factor Xa inhibitors after andexanet, dabigatran, heparins, direct thrombin inhibitors, thrombolytics, and antiplatelets, plus when to restart.
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Heparin Infusion & HIT Quick Card
Weight-based UFH nomograms by indication, anti-Xa versus aPTT monitoring and discordance, heparin resistance, the 4Ts score, and ASH 2018 HIT management with argatroban and bivalirudin dosing.
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Vancomycin AUC Quick Card
AUC-guided targets, empiric dosing, monitoring, and nephrotoxicity: the ASHP/IDSA/SIDP 2020 essentials on one page.
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Aminoglycoside Dosing & TDM Quick Card
Gentamicin, tobramycin, and amikacin: dosing weight, extended-interval and Hartford nomogram rules, two-level kinetics, synergy dosing, dialysis, toxicity, and the CLSI 2023 breakpoint changes.
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Beta-Lactam Extended Infusion Quick Card
Piperacillin-tazobactam, meropenem, and cefepime: EI dosing, stability windows, renal adjustment, and the BLING III evidence, on one printable page.
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Vasopressors Quick Card
The septic-shock escalation ladder: norepinephrine first, vasopressin add-on, refractory options, and steroids, per SSC 2021.
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ICU Analgesia & Sedation Quick Card
Analgesia-first sedation for ventilated adults: CPOT/BPS and RASS targets, paired SAT and SBT, infusion ranges and traps, tapering, and what SPICE III, MENDS2, and A2B showed.
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Status Epilepticus Quick Card
Adult convulsive status epilepticus by the clock: full-dose benzodiazepines, ESETT second-line loads, refractory infusions with EEG targets, phenytoin level correction, and the underdosing trap.
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Opioid Conversion Quick Card
Equianalgesic estimates, the 5-step conversion method, and the safety rules, incomplete cross-tolerance, methadone, and fentanyl patches.
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DKA Insulin Protocol Quick Card
Insulin drip initiation, rate adjustment, BG targets, dextrose add-on, subQ transition criteria, and the pitfalls that cause DKA bounce-back.
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Steroid Equivalencies Quick Card
Glucocorticoid equivalency table, relative potencies, duration classes, conversion method, and taper considerations on one printable page.
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Antidotes & Reversal Agents Quick Card
Acetylcysteine, digoxin immune Fab, fomepizole, naloxone infusions, and protamine, plus the flumazenil cautions and the antidotes you get paged about at 2am.

📚 Full Reference Pages

The long-form pages, organized by specialty. Every indication, dose, adjustment, and monitoring parameter for a drug class in one place. Read these when you need the whole picture, not just the number.

Anticoagulation / Hematology

❤️ Direct Oral Anticoagulants (DOACs)

A PharmD-curated clinical reference for the four FDA-approved DOACs: apixaban, rivaroxaban, dabigatran, and edoxaban.

 🩸 Anticoagulation Reversal

A PharmD reference for reversing warfarin, heparin/LMWH, and DOACs in the setting of major bleeding or an urgent procedure.

Pharmacokinetics / TDM

📈 Vancomycin Therapeutic Drug Monitoring (AUC-guided)

ASHP/IDSA/SIDP 2020 consensus guidelines moved vancomycin monitoring from trough-only to AUC/MIC-guided dosing.

Critical Care / ICU

💉 Vasopressors in Septic Shock

A PharmD reference for vasopressor selection, dosing, and escalation in septic shock. Based on the 2021 SSC guidelines and current evidence.

Infectious Disease / Antimicrobials

🦠 Beta-Lactam Antibiotics: Clinical Overview

A PharmD reference covering the major beta-lactam classes: penicillins, cephalosporins, carbapenems, and monobactams.

Pain Management / Opioids

💊 Pain Management & Opioids

A PharmD reference for opioid selection, equianalgesic conversion, and safe prescribing in acute and chronic pain.

Coming Soon

Renal Dosing Principles Aminoglycosides & TDM COPD Pharmacotherapy Drug-Induced QTc Prolongation

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