PharmD Signal

Deep dives, evidence grades, and clinical tools, all in one place.

🧠 Clinical library

Clinical Specialty Index

131 articles indexed across 16 specialties, each reviewed by a licensed pharmacist before publication.

Showing all 131 articles.Sort: Newest | Oldest
ADA Obesity Association Releases 2026 Adult Obesity Diagnosis and Staging Standards
Endocrinology / Obesity Practice-changing Grade: Moderate

New obesity guidelines emphasize early screening and tailored diagnosis.

LAAC Noninferior to NOACs in Anticoagulation-Eligible AF
Cardiology / Anticoagulation Practice-changing Grade: Moderate

Atrial appendage closure reduces bleeding in atrial fibrillation.

Mirikizumab sustains multidomain UC remission through four years
Gastroenterology / Hepatology Confirmatory Grade: Low

Four-year study shows lasting ulcerative colitis remission with mirikizumab.

Adjuvant TACE and Lenvatinib-Tislelizumab Show Comparable Recurrence Benefit in HCC
Oncology Pharmacy Hypothesis-generating Grade: Low

This retrospective, propensity-matched comparison informs adjuvant regimen selection for resected high-risk hepatocellular carcinoma, weighing locoregional chemoembolization against a targeted-immunotherapy combination.

ESC/EACTS Consensus Refines Antithrombotic Strategy After Bypass Surgery
Cardiology / Anticoagulation Confirmatory Grade: Low

Balance risks: Antithrombotic therapy post-bypass under scrutiny.

Semaglutide cuts heavy drinking in alcohol use disorder with obesity
Behavioral Health / Addiction Medicine Hypothesis-generating Grade: Moderate

Semaglutide reduces alcohol intake in comorbid obesity.

Asundexian Cuts Recurrent Ischemic Stroke Without Excess Bleeding
Cardiology / Anticoagulation Practice-changing Grade: High

Could a new anticoagulant improve stroke prevention?

Surviving Sepsis Campaign 2026 Guidelines Overhaul Adult Sepsis Management
Critical Care / ICU Practice-changing Grade: Moderate

2026 sepsis guidelines enhance antimicrobial and fluid strategies.

Obinutuzumab Improves Response in Active Non-Renal SLE
Rheumatology / Immunology Practice-changing Grade: High

Obinutuzumab improves SLE outcomes in the recent ALLEGORY trial.

Biomarker Strategies for Chemotherapy Cardiotoxicity: Promise Versus Validation
Oncology Pharmacy Confirmatory Grade: Very Low

New biomarkers offer promise for early detection of chemotherapy-induced heart damage.

ADA Standards of Care: Pharmacologic Treatment of Obesity in Adults
Obesity / Weight Management Practice-changing Grade: Moderate

The ADA's new Obesity Association guideline reframes obesity pharmacotherapy around treating obesity-related diseases rather than weight targets alone, elevates GLP-1RA and dual GIP/GLP-1RA agents to preferred status across multiple comorbidities, and mandates indefinite continuation to prevent weight recurrence.

Finerenone Slows eGFR Decline in Non-Diabetic CKD
Chronic Kidney Disease Practice-changing Grade: Moderate

FIND-CKD extends the kidney-protective role of finerenone from diabetic to non-diabetic chronic kidney disease, giving pharmacists a new evidence-based add-on to renin-angiotensin system blockade.

Polymyxin B Haemoadsorption Reduces Mortality in Endotoxic Septic Shock
IDSA Confirmatory Grade: Moderate

TIGRIS trial indicates improved outcomes for patients with specific endotoxin activity in septic shock.

2026 ADA Standards of Care in Diabetes Update
Diabetes Practice-changing Grade: Moderate

Introduces expanded diabetes screening and diagnostic recommendations across diverse populations for pharmacy practice.

GOLD 2026 COPD Strategy: Mepolizumab Enters the Algorithm
COPD Practice-changing Grade: Moderate

GOLD 2026 adds mepolizumab as a second eosinophil-guided biologic option and refines exacerbation-focused escalation, expanding the pharmacist's role in phenotype-driven COPD care.