Endocrinology / Obesity Practice-changing Grade: Moderate
New obesity guidelines emphasize early screening and tailored diagnosis.
Cardiology / Anticoagulation Practice-changing Grade: Moderate
Atrial appendage closure reduces bleeding in atrial fibrillation.
Gastroenterology / Hepatology Confirmatory Grade: Low
Four-year study shows lasting ulcerative colitis remission with mirikizumab.
Oncology Pharmacy Hypothesis-generating Grade: Low
This retrospective, propensity-matched comparison informs adjuvant regimen selection for resected high-risk hepatocellular carcinoma, weighing locoregional chemoembolization against a targeted-immunotherapy combination.
Cardiology / Anticoagulation Confirmatory Grade: Low
Balance risks: Antithrombotic therapy post-bypass under scrutiny.
Behavioral Health / Addiction Medicine Hypothesis-generating Grade: Moderate
Semaglutide reduces alcohol intake in comorbid obesity.
Cardiology / Anticoagulation Practice-changing Grade: High
Could a new anticoagulant improve stroke prevention?
Critical Care / ICU Practice-changing Grade: Moderate
2026 sepsis guidelines enhance antimicrobial and fluid strategies.
Rheumatology / Immunology Practice-changing Grade: High
Obinutuzumab improves SLE outcomes in the recent ALLEGORY trial.
Oncology Pharmacy Confirmatory Grade: Very Low
New biomarkers offer promise for early detection of chemotherapy-induced heart damage.
Obesity / Weight Management Practice-changing Grade: Moderate
The ADA's new Obesity Association guideline reframes obesity pharmacotherapy around treating obesity-related diseases rather than weight targets alone, elevates GLP-1RA and dual GIP/GLP-1RA agents to preferred status across multiple comorbidities, and mandates indefinite continuation to prevent weight recurrence.
Chronic Kidney Disease Practice-changing Grade: Moderate
FIND-CKD extends the kidney-protective role of finerenone from diabetic to non-diabetic chronic kidney disease, giving pharmacists a new evidence-based add-on to renin-angiotensin system blockade.
IDSA Confirmatory Grade: Moderate
TIGRIS trial indicates improved outcomes for patients with specific endotoxin activity in septic shock.
Diabetes Practice-changing Grade: Moderate
Introduces expanded diabetes screening and diagnostic recommendations across diverse populations for pharmacy practice.
COPD Practice-changing Grade: Moderate
GOLD 2026 adds mepolizumab as a second eosinophil-guided biologic option and refines exacerbation-focused escalation, expanding the pharmacist's role in phenotype-driven COPD care.