Endocrinology / Obesity Practice-changing Grade: High
Tirzepatide delivers unprecedented weight loss results in obesity management.
Asthma Practice-changing Grade: Moderate
GINA 2021 formalizes ICS-formoterol as the preferred reliever across all adult/adolescent steps and adds new pediatric and Step 5 options.
Nephrology / Renal Pharmacy Practice-changing Grade: High
Finerenone reduces cardiovascular events in diabetes with kidney disease.
Nephrology / Renal Pharmacy Practice-changing Grade: High
Finerenone reduces kidney and cardiovascular risks in diabetes patients.
Cardiology / Anticoagulation Hypothesis-generating Grade: Moderate
LAAC proves noninferior to DOACs in high-risk AF stroke prevention.
Community-Acquired Pneumonia Practice-changing Grade: Moderate
The 2019 ATS/IDSA CAP guideline introduces major shifts in diagnostic and empiric therapy strategies for adult patients.
Neurology / Neuropharmacology Hypothesis-generating Grade: Moderate
Alteplase shows promise for late-presenting stroke when guided by imaging.
Cardiology / Anticoagulation Hypothesis-generating Grade: Low
Andexanet alfa reduces factor Xa activity by 92% in bleeding emergencies.
Neurology / Neuropharmacology Practice-changing Grade: Moderate
MRI-guided thrombolysis may benefit stroke of unknown onset.
Confirmatory Grade: Low
This systematic review of observational data confirms that continuous subcutaneous levodopa infusions reduce motor fluctuations in advanced Parkinson disease, with infusion-site reactions as the dominant tolerability concern pharmacists must proactively manage.
Practice-changing Grade: High
ACHIEVE-5 provides the first phase 3 evidence that an oral nonpeptide GLP-1 receptor agonist can be layered onto titrated basal insulin to add glycemic and weight benefit without excess hypoglycemia.