Adjunctive Bacteriophage Therapy for Malakoplakia Study

Aug 11, 2026 · Published in: Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

Infectious Disease / Antimicrobials

Background Information

First successful bacteriophage therapy for a transplant infection complication.

This study explores an innovative treatment using bacteriophage therapy for an infection-related complication in a transplant patient, potentially indicating a new therapeutic avenue. The adjunctive bacteriophage therapy, combined with multiple treatments, led to resolution of skin lesions and radiographic improvement without adverse events. Though promising, this is an early-phase case report; broader trials are necessary to establish safety and efficacy. Bacteriophage therapy, combined with antibiotics, shows potential for treating Escherichia coli-related malakoplakia in complex cases.

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Authors: Aslam S, Brubaker A, Shah M, Martin TCS, Mandt T, Windham-Herman AM, Zhang H, Bryde T, Gençay YE, Gram A, Grøndahl C, Haaber JK, Hallström B, van der Helm E, Hink J, Maccario L, Østergaard A, Troy A, Yavari N, Schooley RT, Mehta S

Citation: Aslam S, Brubaker A, Shah M, et al. First-in-Human Adjunctive Bacteriophage Therapy for Malakoplakia. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2026. doi:10.1093/cid/ciag446

Article Links: PubMed · Journal / DOI

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