Single-Dose Prophylaxis Noninferior to Multiple Doses in Hip Arthroplasty
Analysis Perioperative / Anesthesia Confirmatory Grade: Moderate
Abedi AA, Anneberg M, Pedersen AB, et al.
Sep 18, 2026 · Published in: JAMA Network Open
Also in Infectious Disease / Antimicrobials
Single antibiotic dose matches multiple doses in hip surgery infection prevention.
Single-Shot Liposomal Bupivacaine Non-Inferior to Continuous Block After Knee Arthroplasty
Analysis Perioperative / Anesthesia Hypothesis-generating Grade: Low
Pan X, Ye P, Xie Y, et al.
Sep 12, 2026 · Published in: Drug Design, Development and Therapy
Liposomal bupivacaine equals infusion for knee pain, but less opioid use with infusion.
Perioperative Nicotine Withdrawal Amplifies Pain and Opioid Demand
Analysis Perioperative / Anesthesia Hypothesis-generating Grade: Low
Hu SS, Zhang CF, Lkhagvasuren B, et al.
Sep 10, 2026 · Published in: CNS Neuroscience & Therapeutics
Also in Pain Management
Nicotine withdrawal heightens pain, increasing opioid needs post-surgery.
Single-Shot Liposomal Bupivacaine Non-Inferior to Continuous Block After Knee Replacement
Analysis Perioperative / Anesthesia Hypothesis-generating Grade: Low
Sep 7, 2026 · Published in: Drug Design, Development and Therapy
Single-shot liposomal bupivacaine offers a catheter-free alternative for posterior knee pain after TKA, meeting non-inferiority for 72-hour pain relief but with modestly higher opioid use.
High-Dose GLP-1 Agonists Safe in Spine Surgery
Analysis Perioperative / Anesthesia
Stirpe C, Lee B, Lavu M, et al.
Sep 7, 2026 · Published in: The Spine Journal : Official Journal of the North American Spine Society
Also in Endocrinology / Diabetes / Obesity
High-dose GLP-1 therapy is safe for spinal fusion surgery.
Oliceridine Matches Sufentanil, Halves Nausea After Abdominal Surgery
Analysis Perioperative / Anesthesia Confirmatory Grade: Moderate
Li W, Zhao Y, Wang S, et al.
Sep 1, 2026 · Published in: Drug Design, Development and Therapy
Also in Pain Management
Oliceridine matches sufentanil for pain relief, reduces nausea.
Intravenous Dexmedetomidine 0.75 mcg/kg May Optimize Analgesia After Femoral Block
Analysis Perioperative / Anesthesia Hypothesis-generating Grade: Low
Zhai W, Yu Z, Qu Y, et al.
Aug 31, 2026 · Published in: BMJ Open
DEX prolongs analgesia in ACL reconstruction at safer doses.
Pharmacist-Led Framework for Perioperative GLP-1 Agonist Risk Management
Analysis Perioperative / Anesthesia Hypothesis-generating Grade: Low
Shen N, Zhu C, Wang F, et al.
Aug 29, 2026 · Published in: Therapeutics and Clinical Risk Management
Also in Endocrinology / Diabetes / Obesity
Pharmacists can lead the safe perioperative management of GLP-1 receptor agonists.
Ketamine Versus Pregabalin for Opioid Sparing After Spinal Fusion
★ Editor's Pick Analysis Perioperative / Anesthesia Hypothesis-generating Grade: Low
Coffin M, Azhar MZ, Shepherd W, et al.
Aug 7, 2026 · Published in: Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Also in Pain Management, Pharmacokinetics / TDM
Ketamine might outperform pregabalin in reducing opioid use post-spinal fusion.
Esketamine Cuts Pediatric Emergence Delirium After Sevoflurane by Two-Thirds
Analysis Perioperative / Anesthesia Confirmatory Grade: Moderate
Lateiresh M, Louat A, Alwefati M, et al.
Aug 6, 2026 · Published in: Paediatric Anaesthesia
Also in Pediatrics
Esketamine reduces emergence delirium in children post-anesthesia.
Liposomal Bupivacaine Cuts Movement Pain After CRS + HIPEC
Analysis Perioperative / Anesthesia Hypothesis-generating Grade: Low
Zhang H, Gong Z, Li Y, et al.
Aug 2, 2026 · Published in: Pain and Therapy
Also in Pain Management
Can liposomal bupivacaine revolutionize post-surgical pain management in CRS + HIPEC?
Anterior lumbosacral plexus block outperforms lumbar epidural for lower limb surgery
Analysis Perioperative / Anesthesia Hypothesis-generating Grade: Moderate
Kaur S, Mohammed S, Chhabra S, et al.
Aug 1, 2026 · Published in: Journal of Anaesthesiology, Clinical Pharmacology
New block technique outperforms epidurals in lower limb surgery.
Perioperative Dapagliflozin Halves Postoperative AKI After Cardiac Surgery
Analysis Nephrology / Renal Pharmacy Hypothesis-generating Grade: Moderate
Oosterom-Eijmael MJP, Hulst AH, de Oliveira NPM, et al.
Jul 30, 2026 · Published in: JAMA
Also in Perioperative / Anesthesia, Endocrinology / Diabetes / Obesity
Dapagliflozin cuts acute kidney injury risk post-cardiac surgery.
No Advantage for Rhythm Control in Post-Cardiac Surgery AF
Analysis Cardiology Confirmatory Grade: Very Low
Dairi MS, Tarabzoni M, Tarola C, et al.
Jul 29, 2026 · Published in: Frontiers in Cardiovascular Medicine
Also in Perioperative / Anesthesia
Rhythm control offers no clear advantage over rate control post-cardiac surgery.
Aspirin Monotherapy Noninferior to Rivaroxaban Bridge After Arthroplasty
Analysis Anticoagulation / Hematology Practice-changing Grade: High
Shivakumar S, Matino D, Zukor D, et al.
Jul 12, 2026 · Published in: N Engl J Med
Also in Perioperative / Anesthesia
Aspirin matches rivaroxaban's efficacy in preventing post-surgical blood clots.