Pharmacist-Led Framework for Perioperative GLP-1 Agonist Risk Management

This narrative review synthesizes gastric-emptying pharmacodynamics, perioperative outcome data, and divergent guidance into a structured, pharmacist-coordinated workflow for individualized periprocedural GLP-1 receptor agonist decisions.

📅 Journal publication: 2026 (online Aug 24, 2026) · Last updated: Oct 7, 2026

GLP-1 receptor agonistssemaglutidetirzepatideliraglutidedulaglutideexenatidelixisenatideretatrutidedelayed gastric emptyingperioperative managementaspiration riskmedication reconciliationclinical pharmacynarrative reviewobesitytype 2 diabetes Perioperative / Anesthesia

Also in Endocrinology / Diabetes / Obesity

Background Information

Pharmacists can lead the safe perioperative management of GLP-1 receptor agonists.

GLP-1 receptor agonists (GLP-1RAs) are widely used for multiple conditions, posing unique perioperative medication management challenges. No consistent increase in aspiration pneumonia risk was found, but individualized risk management is essential due to potential delayed gastric emptying. Pharmacists can enhance perioperative care by implementing a structured approach for risk management and coordination with surgical teams. Pharmacists should lead individualized perioperative management for GLP-1 RAs to prevent adverse outcomes.

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Authors: Shen N, Zhu C, Wang F, Wu M

Citation: Shen N, Zhu C, Wang F, et al. Medication Safety and Perioperative Risk Management of GLP-1 Receptor Agonists: A Pharmacist-Led Framework for Individualized Care. Therapeutics and clinical risk management. 2026;22:623743. doi:10.2147/TCRM.S623743

Article Links: PubMed · Journal / DOI · Free Full Text (PMC)

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Executive Summary

Study Design

Patient Population

Primary Outcomes

Secondary Outcomes & Safety Profile

Pharmacist Implications

Clinical Pearls

Limitations

Controversies & Evidence Gaps

Cost & Logistics

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