PharmD Signal

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🧠 Clinical library

Clinical Specialty Index

131 articles indexed across 16 specialties, each reviewed by a licensed pharmacist before publication.

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Nephrology / Renal Pharmacy ConfirmatoryGrade: Moderate

Finerenone Outperforms Spironolactone for Cardiorenal Protection in Moderate CKD

Finerenone emerges as the safer choice for CKD patients.

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Neurology / Neuropharmacology ConfirmatoryGrade: Low

Tenecteplase Shortens Stroke Treatment and Transfer Times

Tenecteplase speeds up stroke thrombolysis compared to alteplase.

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Rheumatology / Immunology ConfirmatoryGrade: Moderate

EULAR 2025 Streamlines Rheumatoid Arthritis DMARD Management to Nine Recommendations

New EULAR guidelines redefine RA management with DMARDs.

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Showing all 131 articles.Sort: Newest | Oldest
Finerenone Outperforms Spironolactone for Cardiorenal Protection in Moderate CKD
🔓 Free Teaser Nephrology / Renal Pharmacy Confirmatory Grade: Moderate

Finerenone emerges as the safer choice for CKD patients.

Tenecteplase Shortens Stroke Treatment and Transfer Times
🔓 Free Teaser Neurology / Neuropharmacology Confirmatory Grade: Low

Tenecteplase speeds up stroke thrombolysis compared to alteplase.

EULAR 2025 Streamlines Rheumatoid Arthritis DMARD Management to Nine Recommendations
🔓 Free Teaser Rheumatology / Immunology Confirmatory Grade: Moderate

New EULAR guidelines redefine RA management with DMARDs.

2026 ACC/AHA/Multisociety Dyslipidemia Guideline Reframes Lipid Management and Targets
🔓 Free Teaser Dyslipidemia Practice-changing Grade: Moderate

The 2026 ACC/AHA/Multisociety guideline introduces lower treatment goals, formal risk equations, and mandates Lp(a) assessment for dyslipidemia pharmacists.

2026 AHA/ASA Acute Ischemic Stroke Guideline: Major Shifts in Thrombolysis, EVT, and Systems
🔓 Free Teaser Ischemic Stroke Practice-changing Grade: High

The 2026 AHA/ASA guideline replaces the 2018 guideline and its 2019 update, elevating tenecteplase to a co-first-line thrombolytic with alteplase, endorsing imaging-selected thrombolysis out to 9 hours and in wake-up stroke, expanding endovascular thrombectomy to large ischemic cores and basilar occlusion, and reversing intensive glucose and blood-pressure targets.

Dexmedetomidine vs Clonidine vs Propofol: Extubation in ICU Patients
🔓 Free Teaser Critical Care / ICU

The A2B trial evaluates sedation strategies on extubation timing in critical care.

Dapagliflozin Fails to Reduce Early HF Event Risk in Hospitalized Patients
🔓 Free Teaser Cardiology / Anticoagulation Inconclusive Grade: Low

DAPA ACT HF-TIMI 68 evaluates dapagliflozin's effect in acute heart failure, finding no short-term risk reduction.

2022 AHA/ACC/HFSA Heart Failure Guideline: Major Revisions to GDMT and Phenotypes
🔓 Free Teaser Heart Failure Practice-changing Grade: Moderate

The 2022 AHA/ACC/HFSA guideline redefines heart failure subtypes and updates foundational recommendations for GDMT, SGLT2 inhibitors, and phenotype-directed care.

Brain Trauma Foundation 4th Edition Severe TBI Guidelines Reshape Neurocritical Practice
🔓 Free Teaser Traumatic Brain Injury Practice-changing Grade: Moderate

The BTF 4th Edition revises hyperosmolar, seizure, steroid, ICP-threshold, and sedation guidance most relevant to neuro-ICU pharmacists.

Early LAI Antipsychotics in First 5 Years of Schizophrenia
Ambulatory Care / MTM Confirmatory Grade: Low

Early LAI use in schizophrenia improves outcomes and adherence.

Venetoclax TDM Reduces Toxicity Risk in Posaconazole-Treated AML Patients
Oncology Pharmacy Hypothesis-generating Grade: Low

Venetoclax levels spike with posaconazole: TDM is essential.

Prior IV thrombolysis does not dictate first-line thrombectomy technique
Neurology / Neuropharmacology Confirmatory Grade: Low

Does prior thrombolysis influence thrombectomy effectiveness in stroke recovery?

Structured Scoring Tool Ranks Pediatric Vancomycin PK Models for Precision Dosing
Pharmacokinetics / TDM Confirmatory Grade: Moderate

Optimize vancomycin dosing with precision models in young patients.

Nanocarrier Delivery Systems for Epilepsy: A Preclinical Landscape Review
Neurology / Neuropharmacology Hypothesis-generating Grade: Very Low

Nanocarriers show potential for improving epilepsy drug delivery.

Immunotherapy May Enable Safe Axillary De-escalation in Node-Positive TNBC
Oncology Pharmacy Hypothesis-generating Grade: Low

Chemo-immunotherapy may enable less invasive breast cancer surgeries.