IDSA Multisociety Position Paper: Hospital Strategies to Improve Sepsis Outcomes

A new IDSA-led multisociety consensus prioritizes pharmacist-driven levers including beta-lactam-first sequencing, prolonged-infusion defaults, and second-dose timeliness to improve sepsis outcomes beyond bundle compliance.

IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP Multisociety Position PaperInfectious Diseases Society of Americasepsisseptic shockbeta-lactamsvancomycinantimicrobial stewardshipcorticosteroidsrapid diagnostics Infectious Disease / Antimicrobials

Background Information

Hospital strategies to combat sepsis can significantly improve outcomes.

Sepsis is a leading cause of morbidity and mortality in hospitals despite existing guidelines and measures. The paper provides evidence-informed recommendations to improve sepsis management across six domains, such as diagnostic testing and antimicrobial management. The recommendations offer practical strategies that complement existing frameworks and can enhance hospital sepsis outcomes if implemented. Comprehensive, multidisciplinary recommendations can improve sepsis management and patient outcomes in hospitals.

📊 Deep Analysis Available

Subscribers get the full breakdown: study design, outcomes, pharmacist implications, clinical pearls, GRADE evidence grade, and a downloadable PDF report.

Subscribe for Full Access →

Authors: Rhee C, Masur H, Klompas M, Bell T, Busch LM, Chiotos K, Classen D, Gilbert D, Heil EL, Hou C, Kadri SS, Kalil AC, Palavecino EL, Patel SJ, Septimus EJ, Sevransky J, Simpson SQ, Strich JR, Sweeney DA, Talari P, Taylor SP, Winslow D, Yealy DM, Griffin FA, Cosgrove SE

Citation: Rhee C, Masur H, Klompas M, et al. IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP Multisociety Position Paper: Hospital Strategies to Improve Sepsis Outcomes. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2026. doi:10.1093/cid/ciag438

Article Links: PubMed · Journal / DOI

🎓

Reviewed by a licensed pharmacist

Every analysis is reviewed and approved by a licensed pharmacist before publication, ensuring clinical accuracy and relevance.

Accurate and up-to-date information is our highest priority.

If you spot an error, please suggest a correction. If there is a topic you want covered, tell us and we will look at it.

Suggest a correction Request a topic

Thanks for the feedback!

🔒

Deep Analysis: Subscribers Only

Subscribers receive access to a complete clinical analysis, available online and as a downloadable PDF.

Executive Summary

Study Design

Patient Population

Primary Outcomes

Secondary Outcomes & Safety Profile

Pharmacist Implications

Clinical Pearls

Limitations

Controversies & Evidence Gaps

Cost & Logistics

Want the full analysis?

Subscribe to PharmD Signal for unrestricted access to every deep analysis, plus PDF reports, GRADE evidence grades, and pharmacist implications for every article we publish.

Become a Subscriber →