EAS Consensus Lowers Age and LDL-C Targets for Pediatric FH

This consensus statement recalibrates diagnostic thresholds, treatment initiation age, and LDL-C goals for children with familial hypercholesterolaemia, expanding the pharmacist's role in early lipid-lowering therapy.

familial hypercholesterolaemiaHeFHHoFHstatinsezetimibePCSK9 inhibitorsevinacumablomitapideinclisiranlipoprotein apheresispediatric dyslipidemiaLDL cholesterolcardiovascular preventionEAS consensusscreening Guideline: Dyslipidemia

Background Information

Early FH detection in children can extend life expectancy.

Early diagnosis and treatment of familial hypercholesterolaemia (FH) in children can significantly improve life expectancy and reduce the risk of premature cardiovascular disease. Revised diagnostic criteria and treatment goals for LDL cholesterol (LDL-C) in children with FH are presented, emphasizing early screening and initiation of lipid-lowering therapies (LLTs). The guideline highlights the need for pediatric FH screening programs and updated LDL-C treatment goals, which can enhance early intervention strategies. Implementing pediatric FH screening and early LLT can drastically improve long-term outcomes.

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Authors: Wiegman A, Bourbon M, Freiberger T, Gidding SS, Greber-Platzer S, Groselj U, Holven KB, Hudgins LC, Humphries SE, Hutten BA, Ibarretxe D, Pederiva C, Peretti N, Raal FJ, Ramaswami U, Sanin V, Santos RD, Steinhagen-Thiessen E, Watts GF, Perkins R, Benn M, Binder CJ, Romeo S, Roeters van Lennep JE

Citation: Wiegman A, Bourbon M, Freiberger T, et al. Familial hypercholesterolaemia in children and adolescents: a European Atherosclerosis Society consensus statement. European heart journal. 2026;47(26):3324-3346. doi:10.1093/eurheartj/ehag382

Article Links: PubMed · Journal / DOI · Free Full Text (PMC)

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