IABP Support Linked to Higher Vancomycin Troughs After Combined CABG and Valve Surgery
Analysis Pharmacokinetics / TDM Hypothesis-generating Grade: Low
Shao BB, Feng T, Jiang JC, et al.
Oct 27, 2026 · Published in: Frontiers in Pharmacology
Also in Cardiology, Infectious Disease / Antimicrobials
Exploring new factors influencing vancomycin levels after complex heart surgeries.
Bayesian Tobramycin Dosing in Cystic Fibrosis Exposes Hidden Underexposure
Analysis Pharmacokinetics / TDM Hypothesis-generating Grade: Very Low
Johnson E, Williams M, Henderson D, et al.
Oct 18, 2026 · Published in: European Journal of Clinical Pharmacology
Also in Infectious Disease / Antimicrobials
Bayesian TDM redefines tobramycin dosing in cystic fibrosis.
Busulfan Precision Dosing Evolves From TDM Toward Model-Informed Dosing
Analysis Pharmacokinetics / TDM Confirmatory Grade: Low
Zhang XY, Li Y, Xu J, et al.
Sep 26, 2026 · Published in: Pharmaceutics
Also in Oncology, Pediatrics
Optimizing busulfan dosing in pediatric transplants involves bridging TDM with precision models.
AUC-guided Bayesian vancomycin dosing improves targets, renal signal unconfirmed
Analysis Pharmacokinetics / TDM Hypothesis-generating Grade: Low
Gundlach L, Kunkel M, Scherf-Clavel O, et al.
Sep 19, 2026 · Published in: BMC Pharmacology & Toxicology
Bayesian AUC dosing raised target attainment and cut supratherapeutic levels, but the AKI benefit vanished after adjustment.
LLMs Recognize TDM Problems but Reason Overconfidently on NTI Drugs
Analysis Pharmacokinetics / TDM Hypothesis-generating Grade: Low
Azmakan H, Azamakan T
Sep 18, 2026 · Published in: Journal of the American Pharmacists Association : JAPhA
Also in Medication Safety
LLMs show promise for drug monitoring, yet caution remains due to potential reasoning errors.
Voriconazole Dose Reduction Often Fails to Correct High Troughs
Analysis Pharmacokinetics / TDM Hypothesis-generating Grade: Low
He T, Liu Z, Liang L, et al.
Sep 17, 2026 · Published in: Frontiers in Pharmacology
Voriconazole TDM reveals persistent supratherapeutic levels after dose adjustment in hospitalised patients.
Isavuconazole for chronic pulmonary aspergillosis: tolerability and TDM-guided dosing
Analysis Pharmacokinetics / TDM Hypothesis-generating Grade: Low
Fama F, Conflitti C, Civati A, et al.
Sep 16, 2026 · Published in: Antimicrobial Agents and Chemotherapy
Standard isavuconazole dosing often overshoots in chronic pulmonary aspergillosis, so early troughs can guide a step down to 100 mg daily.
PBPK model predicts modestly lower acetaminophen exposure in pregnancy
Analysis Women's Health / Reproductive Hypothesis-generating Grade: Very Low
Kong W, Yang Y, Guan X, et al.
Sep 8, 2026 · Published in: Pakistan Journal of Pharmaceutical Sciences
Also in Pharmacokinetics / TDM
Pregnancy alters acetaminophen metabolism—dose adjustments needed!
Optimizing Drug Dosing in Diabetic Kidney Disease
Analysis Pharmacokinetics / TDM
Mousavi T, Shaya FT, Munir KM, et al.
Sep 8, 2026 · Published in: Expert Opinion on Drug Metabolism & Toxicology
Also in Nephrology, Endocrinology / Diabetes / Obesity
Tailored dosing strategies are key in diabetic kidney disease drug therapy.
PBPK Model Guides Age-Specific Posaconazole Suspension Dosing With Meals
Analysis Pharmacokinetics / TDM Hypothesis-generating Grade: Low
Wu J, Qin X, Huang X, et al.
Sep 7, 2026 · Published in: Drug Design, Development and Therapy
Also in Infectious Disease / Antimicrobials, Pediatrics
Optimize pediatric posaconazole dosing with food intake insights.
Two-Sample 3-and-7-Hour Schedule Optimizes Once-Daily Busulfan TDM
Analysis Pharmacokinetics / TDM Confirmatory Grade: Low
Tan Z, Achini-Gutzwiller FR, Lankester AC, et al.
Sep 1, 2026 · Published in: Journal of Clinical Pharmacology
Enhance busulfan dosing with a precise two-sample strategy.
Bilirubin-Guided Voriconazole Dosing Improves Target Attainment in Liver Dysfunction
Analysis Pharmacokinetics / TDM Hypothesis-generating Grade: Low
Li J, Zhao Y, Liu H, et al.
Aug 27, 2026 · Published in: Frontiers in Pharmacology
Also in Gastroenterology / Hepatology
Optimized voriconazole dosing enhances outcomes in liver dysfunction.
TDM Not Yet Justified for Non-Anti-TNF IBD Therapies
Analysis Pharmacokinetics / TDM Confirmatory Grade: Low
Chater F, Butler TD, Limdi JK
Aug 19, 2026 · Published in: Frontiers in Gastroenterology (Lausanne, Switzerland)
Also in Gastroenterology / Hepatology
Could TDM unlock better outcomes for advanced IBD therapies?
Ketamine Versus Pregabalin for Opioid Sparing After Spinal Fusion
★ Editor's Pick Analysis Perioperative / Anesthesia Hypothesis-generating Grade: Low
Coffin M, Azhar MZ, Shepherd W, et al.
Aug 7, 2026 · Published in: Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Also in Pain Management, Pharmacokinetics / TDM
Ketamine might outperform pregabalin in reducing opioid use post-spinal fusion.
Vancomycin Trough Near 15.9 mg/L Flags Nephrotoxicity Risk
Analysis Pharmacokinetics / TDM Confirmatory Grade: Low
Chen S, Zhang Y, Hou X, et al.
Jul 27, 2026 · Published in: Infection and Drug Resistance
Vancomycin trough over 15.9 mg/L linked to kidney injury.