This simulation study defines a clinically practical limited sampling strategy for model-informed precision dosing of once-daily intravenous busulfan in adults and adolescents.
Enhance busulfan dosing with a precise two-sample strategy.
Busulfan has a narrow therapeutic index and high pharmacokinetic variability, making precise dosing critical in hematopoietic stem cell transplantation. A two-sample strategy at 3 and 7 hours post-infusion was most effective, doubling target attainment compared to a single-sample method. This study offers evidence for an optimal sampling strategy in therapeutic drug monitoring for busulfan, essential for improving dosing accuracy. A two-sample strategy significantly enhances busulfan target attainment in transplantation settings.
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Executive Summary
Study Design
Patient Population
Primary Outcomes
Secondary Outcomes & Safety Profile
Pharmacist Implications
Clinical Pearls
Limitations
Controversies & Evidence Gaps
Cost & Logistics
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