CPIC 2022 Update: CYP2C19 Genotype and Clopidogrel Therapy
Pharmacogenomics Practice-changing Grade: Moderate
Pharmacogenomics Practice-changing Grade: Moderate
The strength of recommendation to avoid clopidogrel in CYP2C19 intermediate metabolizers is elevated to strong, and genotype-guided antiplatelet therapy now formally extends to neurovascular indications.