Network Meta-Analysis Ranks 21 Antidepressants for Acute Depression
Analysis Psychiatry / Psychopharmacology Practice-changing Grade: Moderate
Cipriani A, Furukawa TA, Salanti G, et al.
Aug 1, 2026 · Published in: Focus (American Psychiatric Publishing)
Antidepressants show varied efficacy and acceptability for major depressive disorder.
GLP-1 Agonists Linked to Lower Antidepressant and Addiction Drug Starts
Analysis Endocrinology / Diabetes / Obesity Hypothesis-generating Grade: Low
Alfonso Arvez MJ, Wade S, Goordeen D, et al.
Jul 31, 2026 · Published in: Clinical Pharmacology and Therapeutics
Also in Psychiatry / Psychopharmacology
GLP-1RAs linked to reduced need for antidepressants and addiction medications.
Dose-Specific Network Meta-Analysis Reaffirms Antipsychotics for Acute Mania
Analysis Psychiatry / Psychopharmacology Confirmatory Grade: Low
Fornaro M, Di Lorenzo C, Kishi T, et al.
Jul 29, 2026 · Published in: Journal of Affective Disorders
Risperidone tops the list for acute bipolar mania efficacy.
Age-Specific Pharmacotherapy Considerations in Older-Age Bipolar Disorder
Analysis Geriatrics / Geriatric Pharmacy Confirmatory Grade: Low
Asir B, Al-Soleiti M, Singh B
Jul 17, 2026 · Published in: Drugs & Aging
Also in Psychiatry / Psychopharmacology
Bipolar disorder in older adults demands unique pharmacotherapy approaches.
DISCARD Trial: Linear vs Hyperbolic Antidepressant Tapering Protocol
Analysis Psychiatry / Psychopharmacology Hypothesis-generating Grade: Very Low
Ostuzzi G, Gastaldon C, Zaccoletti D, et al.
Jul 16, 2026 · Published in: BMJ Open
Exploring safer ways to stop antidepressants in remitted depression.
Sertraline TDM: Weak Signal, No Routine Role Yet
Analysis Pharmacokinetics / TDM Hypothesis-generating Grade: Very Low
Canga-Espina C, Bullard JP, Tapia-Alzuguren B, et al.
Jul 14, 2026 · Published in: Frontiers in Pharmacology
Also in Psychiatry / Psychopharmacology
Is TDM the key to personalized sertraline dosing?
Modeling Supports One-Day Oral Overlap for Aripiprazole LAI Start in Japan
Analysis Psychiatry / Psychopharmacology Confirmatory Grade: Low
Yamasaki Y, Sasaki T, Martinecz A, et al.
Jul 7, 2026 · Published in: Journal of Clinical Pharmacology
New aripiprazole regimen may enhance adherence in schizophrenia and bipolar I disorder.
Sepsis survivors carry elevated psychiatric risk for five years
Analysis Critical Care / ICU Confirmatory Grade: Moderate
Wetterberg H, Nilsson A, Linder A, et al.
Jul 1, 2026 · Published in: Critical Care Medicine
Also in Psychiatry / Psychopharmacology
Sepsis survivors face an increased risk of developing psychiatric disorders.
Oral Prolonged-Release Ketamine Misses Primary Endpoint, Avoids Dissociation
Analysis Psychiatry / Psychopharmacology Hypothesis-generating Grade: Low
Walter M, Zu Eulenburg C, Damyanova A, et al.
Jun 1, 2026 · Published in: JAMA Network Open
Oral KET01 potentially offers safer, at-home depression treatment.
Esketamine Monotherapy Shows Rapid Efficacy in Treatment-Resistant Depression
Analysis Psychiatry / Psychopharmacology Confirmatory Grade: Moderate
Janik A, Qiu X, Lane R, et al.
Sep 1, 2025 · Published in: JAMA Psychiatry
Esketamine offers new hope for treatment-resistant depression monotherapy.
Fixed Low-Dose Oral Esketamine Fails in Treatment-Resistant Depression
Analysis Psychiatry / Psychopharmacology Inconclusive Grade: Low
Smith-Apeldoorn SY, Veraart JKE, Kamphuis J, et al.
Sep 1, 2024 · Published in: Molecular Psychiatry
Oral esketamine may be effective only at higher doses for resistant depression.