Bayesian Synthesis Finds LAAO Fails Stroke Non-Inferiority Versus Anticoagulation
Cardiology / Anticoagulation Confirmatory Grade: Moderate
Athmakuri KS, Nandyal SR, Pamreddy HR, et al.
📅 Jul 22, 2026 · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
LAAO reduces bleeding but not strokes compared to anticoagulation.
Complementary SGLT2 Inhibitor Plus GLP-1 Agonist Therapy in Type 2 Diabetes
Endocrinology / Obesity Confirmatory Grade: Moderate
Porterfield LR, Nadeem S, Swanson D, et al.
📅 Jul 18, 2026 · Current atherosclerosis reports
Combining SGLT2is and GLP-1RAs may revolutionize diabetes management.
EuroGuiDerm 2025 Acne Update: Antibiotic Limits, Hormonal Options
Women's Health Confirmatory Grade: Moderate
Nast A, Al Wattar BH, Beylot Barry M, et al.
📅 Jul 18, 2026 · Journal of the European Academy of Dermatology and Venereology : JEADV
Revamped acne treatment guidelines emphasize isotretinoin and hormonal therapies.
Low-Dose Thrombolysis Plus Argatroban Signals Benefit in Ischemic Stroke
Neurology / Neuropharmacology Hypothesis-generating Grade: Very Low
Huang S, Wang X, Li D, et al.
📅 Jul 18, 2026 · Medicine
Combining tenecteplase with argatroban might enhance stroke recovery.
DISCARD Trial: Linear vs Hyperbolic Antidepressant Tapering Protocol
Psychiatry / Psychopharmacology Hypothesis-generating Grade: Very Low
Ostuzzi G, Gastaldon C, Zaccoletti D, et al.
📅 Jul 16, 2026 · BMJ open
Exploring safer ways to stop antidepressants in remitted depression.
Extended DAPT Cuts Ischemic Events in Multivessel CAD
Cardiology / Anticoagulation Practice-changing Grade: Moderate
Tian J, Wang Z, Wang Y, et al.
📅 Jul 16, 2026 · N Engl J Med
Extended DAPT reduces ischemic events post-stent in multivessel CAD.
Two-Year Lenalidomide Maintenance Matches Indefinite Therapy in Standard-Risk Myeloma
Oncology Pharmacy Practice-changing Grade: Moderate
Kumar S, Jacobus S, Cohen A, et al.
📅 Jul 16, 2026 · N Engl J Med
Two-year lenalidomide is as effective as indefinite therapy in multiple myeloma.
Dupilumab After JAK Inhibitor Withdrawal: Small Real-World Signal
Rheumatology / Immunology Hypothesis-generating Grade: Very Low
Wang Q, Yang G, Li Y, et al.
📅 Jul 16, 2026 · Frontiers in immunology
Switching from JAK inhibitors to dupilumab shows promise in atopic dermatitis management.
Half of Immunocompromised Sepsis Patients Lack Bacterial Infection
Critical Care / ICU Hypothesis-generating Grade: Low
Gupta S, Millham L, DelloStritto L, et al.
📅 Jul 15, 2026 · Critical Care Explorations
Immunocompromised sepsis patients often lack bacterial infection confirmation.
AGA Expert Review Reframes C difficile Management in IBD
Guideline: IDSA Confirmatory Grade: Low
Khanna S, Allegretti JR, Hashash JG, et al.
📅 Jul 15, 2026 · Gastroenterology
CDI poses higher risks for IBD patients, complicating management strategies.
Adjuvant TACE and Lenvatinib-Tislelizumab Show Comparable Post-Resection Benefit
Oncology Pharmacy Hypothesis-generating Grade: Low
Feng X, Ao Y, Wang L, et al.
📅 Jul 14, 2026 · Frontiers in immunology
Adjuvant therapies improve survival in high-risk liver cancer patients.
Buprenorphine-Naloxone Cuts Nonfatal Overdose vs XR Naltrexone Post-Withdrawal
Pain / Palliative Care Confirmatory Grade: Moderate
Hsu HE, Lodi S, Yan S, et al.
📅 Jul 14, 2026 · JAMA network open
Buprenorphine-naloxone reduces overdose risk more effectively than XR naltrexone.
Stepped-Care Smoking Cessation: Meds First, Devices and Harm Reduction Later
Behavioral Health / Addiction Medicine Confirmatory Grade: Low
Croghan IT, Hurt RT, Elrashidi MY, et al.
📅 Jul 13, 2026 · Journal of primary care & community health
Maximize smoking cessation success with new digital and harm-reduction tools.
North Carolina Pharmacists Ambivalent but Willing on Methadone Dispensing
Pain / Palliative Care Hypothesis-generating Grade: Low
Carpenter DM, Shubel C, Marley GT, et al.
📅 Jul 13, 2026 · Journal of addiction medicine
Pharmacists willing but cautious with methadone services for OUD.
Aspirin Monotherapy Noninferior to Rivaroxaban Bridge After Arthroplasty
Cardiology / Anticoagulation Practice-changing Grade: High
Shivakumar S, Matino D, Zukor D, et al.
📅 Jul 12, 2026 · N Engl J Med
Aspirin matches rivaroxaban's efficacy in preventing post-surgical blood clots.