Deep dives, evidence grades, and clinical tools, all in one place.
CrCl & eGFR Dose-Adjustment Calculator
Cockcroft-Gault CrCl & 2021 CKD-EPI eGFR. All calculations run locally in your browser. No data is transmitted.
⚠️
For licensed healthcare professional reference only.
This tool is intended as an educational aid and quick reference for clinically trained professionals. Results must be verified against current drug prescribing information, institutional protocols, and patient-specific clinical factors.
Do not make clinical decisions based solely on this calculator.
PharmD Signal assumes no liability for clinical decisions made using this tool. This is not a substitute for clinical judgment.
kg
Clinical note: Enter actual body weight (ABW). For obese patients, consider adjusted body weight (AdjBW) per institutional protocol. Cockcroft-Gault was validated with ABW.
Results
CrCl (Cockcroft-Gault)
mL/min
eGFR (2021 CKD-EPI)
mL/min/1.73m²
Kidney Function Staging & Dose Adjustment Reference
Based on CrCl (Cockcroft-Gault), the primary metric used in most US drug labeling for dose adjustment. KDIGO staging uses eGFR. Your result is highlighted.
⚠ Always verify dose adjustments against current prescribing information. Thresholds vary by drug. This tool is for educational purposes only and does not constitute clinical advice.
Formulas Used
Cockcroft-Gault CrCl
CrCl = ((140 − Age) × Weightkg) ÷ (72 × SCrmg/dL)
× 0.85 (multiply by 0.85 if female)