Adding IV Aspirin to Cangrelor in Thrombectomy: No Signal, No Proof
This registry analysis of 644 thrombectomy patients compares cangrelor alone with cangrelor plus intravenous aspirin, informing pharmacists who support periprocedural antiplatelet protocols in neurointervention.
📅 Journal publication: Oct 5, 2026·Last updated: Oct 30, 2026
Is aspirin necessary with cangrelor in stroke thrombectomies?
In mechanical thrombectomy for stroke, optimizing platelet inhibition may influence outcomes and safety. There were no significant differences in 90-day outcomes between cangrelor alone and cangrelor with aspirin. The results suggest similar outcomes for cangrelor monotherapy and combination therapy; further studies are needed to confirm findings. Cangrelor alone may be as effective as with aspirin during thrombectomy, but more evidence is needed.
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Authors:Milnerowicz M, Cagnazzo F, Desilles JP, Kyheng M, Labreuche J, Consoli A, Gory B, Dumas V, Caroff J, Veunac L, Clarençon F, Gentric JC, Cognard C, Rouchaud A, Soize S, Lapergue B, Marnat G, ETIS Investigators (see Appendix)
Citation:Milnerowicz M, Cagnazzo F, Desilles JP, et al. Intraoperative cangrelor during mechanical thrombectomy: is the systematic addition of aspirin needed?. European stroke journal. 2026;11(10). doi:10.1093/esj/aakag124