DAPT Shows Promise in Specific Minor Stroke Cases

Oct 6, 2026 · Published in: Brain and Behavior

📅 Journal publication: Oct 2026 · Last updated: Oct 8, 2026

Background Information

Could DAPT be superior to alteplase for certain minor strokes?

Understanding the efficacy of dual antiplatelet therapy (DAPT) versus alteplase for minor stroke can guide treatment decisions based on stroke specifics. In patients with minor stroke and large artery atherosclerosis (LAA), DAPT showed higher 90-day functional outcomes compared to alteplase for NIHSS scores 0-3. Subgroup analysis suggests potential benefit of DAPT over alteplase in specific minor stroke cases but requires further confirmation. DAPT may benefit minor stroke patients with large artery atherosclerosis and NIHSS 0-3, but results need further validation.

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Authors: Cui Y, Li ZA, He C, Chen HS

Citation: Cui Y, Li ZA, He C, et al. NIHSS and Large Artery Atherosclerosis Affect Efficacy of Dual Antiplatelet Therapy Versus Alteplase for Minor Stroke. Brain and behavior. 2026;16(10):e71813. doi:10.1002/brb3.71813

Article Links: PubMed · Journal / DOI · Free Full Text (PMC)

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