Acoramidis Slows Health Status Decline in ATTR-CM

This prespecified secondary analysis of ATTRibute-CM quantifies acoramidis's patient-reported health status benefit in transthyretin amyloid cardiomyopathy, complementing its established mortality and hospitalization reductions.

acoramidistafamidisvutrisiranTTR stabilizertransthyretin amyloid cardiomyopathyATTR-CMheart failurepatient-reported outcomesKCCQsecondary analysisrandomized controlled trial Cardiology / Anticoagulation

Background Information

Acoramidis significantly improves quality of life for ATTR-CM patients.

Acoramidis offers a new potential treatment option for improving heart failure-related health outcomes in transthyretin amyloid cardiomyopathy (ATTR-CM) patients. Acoramidis showed a significant improvement in Kansas City Cardiomyopathy Questionnaire Overall Summary scores with a least-squares mean difference of 9.9 points compared to placebo at 30 months. These findings highlight acoramidis' impact on patient-reported outcomes, suggesting it may alter disease progression in ATTR-CM. The study is robust, indicating meaningful clinical benefit. Acoramidis substantially improves heart failure health status in ATTR-CM patients, suggesting it modifies disease progression.

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Authors: Sherrod CF 4th, Fontana M, Gillmore JD, Kastritis E, Mitchell JD, Krejci J, Tauras JM, van der Meer P, Chen C, Falvey H, Siddhanti S, Tamby JF, Fox JC, Cappelli F, Masri A, Garcia-Pavia P, Hanna M, Sperry BW

Citation: Sherrod CF 4th, Fontana M, Gillmore JD, et al. Effect of Acoramidis on Heart Failure-Related Health Status: A Secondary Analysis of the ATTRibute-CM Randomized Clinical Trial. JAMA cardiology. 2026. doi:10.1001/jamacardio.2026.2413

Article Links: PubMed · Journal / DOI · Free Full Text (PMC)

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