Two Decades of PICU Infection Risk Factors Synthesized

This systematic review updates the evidence base for pediatric-specific nosocomial infection risk factors, giving ICU pharmacists concrete targets for stewardship and device-care interventions.

📅 Journal publication: Oct 2026 (online Jul 29, 2026) · Last updated: Oct 7, 2026

nosocomial infectionpediatric intensive care unitPICUventilator-associated pneumoniacatheter-associated urinary tract infectionbloodstream infectionCLABSImulti-drug-resistant infectionantimicrobial stewardshipparenteral nutritionglucocorticoidssystematic reviewinfection prevention Critical Care / ICU

Background Information

Targeted strategies can help prevent infections in pediatric ICUs.

Nosocomial infections (NIs) significantly increase morbidity and mortality in pediatric intensive care units (PICUs), necessitating updated infection prevention strategies. The review identified risk factors such as younger age, prolonged stay, invasive procedures, and inappropriate antimicrobial use as contributors to NIs among 74,960 children. Highlights the need for tailored strategies like infection control bundles and surveillance, urging large studies for standardized prevention guidelines. Limitations include reliance on observational data. Targeted infection control can mitigate nosocomial infections in PICUs.

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Authors: Wang L, Feng M, Luo Y, Wang C, Wang H, Zhang Y, Huang X, Huang M, Tian Y

Citation: Wang L, Feng M, Luo Y, et al. A systematic review of paediatric-specific risk factors for nosocomial infections in paediatric intensive care units, 2005-2024. The Journal of hospital infection. 2026;176:107-125. doi:10.1016/j.jhin.2026.07.024

Article Links: PubMed · Journal / DOI

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Executive Summary

Study Design

Patient Population

Primary Outcomes

Secondary Outcomes & Safety Profile

Pharmacist Implications

Clinical Pearls

Limitations

Controversies & Evidence Gaps

Cost & Logistics

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