Improving Medication Adherence in Heart Failure

📅 Jun 25, 2026 · BMJ open

Background Information

Can simplification improve heart failure medication adherence?

Heart failure patients often experience polypharmacy, which can hinder adherence to crucial heart failure therapies, impacting outcomes. The PERSEUS-HF trial will assess whether a comprehensive medication management programme improves adherence by using strategies like deprescribing based on Beers Criteria in elderly patients. If effective, this programme could help optimize therapy in heart failure patients with polypharmacy, but findings are pending as this is a study protocol. Evaluating medication management strategies could enhance adherence in heart failure patients with polypharmacy.

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Authors: Kagami K, Kondo T, Suzuki S, Saito Y, Fujiki S, Takahashi S, Iwano H, Omote K, Jujo K, Nagatomo Y, Abe H, Kinugasa Y, Tanabe J, Sakamoto T, Araki T, Minamisawa M, Ishii H, Obokata M

Citation: Kagami K, Kondo T, Suzuki S, et al. Efficacy of a comprehensive medication management programme on medication adherence in patients with heart failure and polypharmacy (PERSEUS-HF): study protocol for a multicentre randomised controlled trial. BMJ open. 2026;16(6):e116761. doi:10.1136/bmjopen-2026-116761

Article Links: PubMed · Journal / DOI · Free Full Text (PMC)

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