Pharmacist Education Triples In-Range Tacrolimus in Pediatric Transplant

This multicenter interventional study quantifies how clinical pharmacist-led drug-related problem resolution and structured caregiver and nurse education, not routine labs, drive therapeutic-range attainment of tacrolimus in pediatric bone marrow transplantation.

tacrolimuscalcineurin inhibitortherapeutic drug monitoringpediatric bone marrow transplantationhematopoietic stem cell transplantationclinical pharmacistdrug-related problemsPCNEmedication educationinterventional study Pharmacokinetics / TDM

Background Information

Tacrolimus control improves with pharmacist-led interventions in BMT.

Tacrolimus management in pediatric BMT is challenging due to its narrow therapeutic index and variability. Patients in therapeutic range increased from 52.3% to 84.4% post-intervention and remained stable at 82.5% after 3 months; 77.1% of interventions were resolved. This study highlights the importance of pharmacist-led education and intervention in maintaining therapeutic drug levels in pediatric transplant patients. Pharmacist intervention improves tacrolimus control in pediatric BMT.

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Authors: Ozturk N, Çattık BN, Malbora B, Akıncı AB, Aksoy BA, Ece D, Fişgin T, Gündoğdu M, Erdem M, Çelen SS, Aksoy N

Citation: Ozturk N, Çattık BN, Malbora B, et al. Impact of clinical pharmacist-led medication management and education on tacrolimus therapeutic control. Frontiers in medicine. 2026;13:1851388. doi:10.3389/fmed.2026.1851388

Article Links: PubMed · Journal / DOI · Free Full Text (PMC)

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Executive Summary

Study Design

Patient Population

Primary Outcomes

Secondary Outcomes & Safety Profile

Pharmacist Implications

Clinical Pearls

Limitations

Controversies & Evidence Gaps

Cost & Logistics

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