SDD Linked to Increased Tobramycin Resistance in E. coli

📅 Jun 23, 2026 · The Journal of antimicrobial chemotherapy

Background Information

SDD increases tobramycin resistance gene prevalence in E. coli.

Selective digestive decontamination (SDD) is used to prevent infections in ICU patients, but its impact on antibiotic resistance is not fully understood. SDD did not significantly change the E. coli pangenome, but it increased the prevalence of a tobramycin resistance gene in E. coli. Though SDD is effective for patient outcomes, it may contribute to resistance gene prevalence, necessitating cautious use in ICUs. SDD impacts antibiotic resistance gene prevalence but not the overall E. coli pangenome.

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Authors: Paganini JA, Schürch AC, Scharringa J, Bonten MJM, Willems RJL, Plantinga NL

Citation: Paganini JA, Schürch AC, Scharringa J, et al. Impact of selective digestive decontamination on the pangenome composition of ESBL-E. coli. The Journal of antimicrobial chemotherapy. 2026;81(7). doi:10.1093/jac/dkag223

Article Links: PubMed · Journal / DOI · Free Full Text (PMC)

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