ICU Meningitis and Encephalitis: Time-Critical Antimicrobials and ICP Control

This narrative review consolidates evidence-based pharmacotherapy and intracranial pressure strategies that frame the ICU pharmacist's role in rapid, pathogen-directed management of central nervous system (CNS) infections.

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Background Information

Swift ICU action saves lives in meningitis cases.

Meningitis and encephalitis require urgent ICU management due to potential severe complications. Early antimicrobial treatment with optional adjuvant steroids improves outcomes; manage seizures, intracranial pressure, and potential neurosurgical needs. Ensures ICU teams prioritize quick diagnosis, appropriate interventions, and manage complications effectively. Swift, targeted ICU interventions can save lives in meningitis and encephalitis cases.

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Authors: Marquez D, Dangayach NS

Citation: Marquez D, Dangayach NS Intensive Care Unit Management of Meningitis and Encephalitis. Critical care clinics. 2026;42(3):481-498. doi:10.1016/j.ccc.2026.01.006

Article Links: PubMed · Journal / DOI

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Executive Summary

Study Design

Patient Population

Primary Outcomes

Secondary Outcomes & Safety Profile

Pharmacist Implications

Clinical Pearls

Limitations

Controversies & Evidence Gaps

Cost & Logistics

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