This narrative review consolidates pivotal trial and real-world data on venetoclax-based doublets, triplets, and emerging immune combinations across newly diagnosed and relapsed/refractory chronic lymphocytic leukemia, clarifying where the evidence supports fixed-duration, chemotherapy-free management.
Venetoclax brings new promise to chronic lymphocytic leukemia management.
Venetoclax-based therapies represent a significant advance in treating chronic lymphocytic leukemia by offering chemotherapy-free options. Studies show high response rates and durable progression-free survival with venetoclax combinations, outperforming chemoimmunotherapy. While promising, the superiority of MRD-guided strategies over fixed-duration treatments remains unclear, highlighting a need for more data. Venetoclax combinations enhance CLL management, providing effective non-chemotherapy options.
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Executive Summary
Study Design
Patient Population
Primary Outcomes
Secondary Outcomes & Safety Profile
Pharmacist Implications
Clinical Pearls
Limitations
Controversies & Evidence Gaps
Cost & Logistics
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