Automated Plasma p-tau217 Accurately Detects Alzheimer Pathology Across Care Settings

This multicohort validation gives neurology pharmacists concrete accuracy, cutoff, and workflow data for a scalable blood test that can gate amyloid-targeting therapy eligibility.

phospho-tau217p-tau217plasma biomarkerLumipulseAlzheimer's diseaseamyloiddiagnostic accuracyblood-based biomarkermass spectrometryprimary careneurologydementia Neurology / Neuropharmacology

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Authors: Palmqvist S, Warmenhoven N, Anastasi F, Pilotto A, Janelidze S, Tideman P, Stomrud E, Mattsson-Carlgren N, Smith R, Ossenkoppele R, Tan K, Dittrich A, Skoog I, Zetterberg H, Quaresima V, Tolassi C, Höglund K, Brugnoni D, Puig-Pijoan A, Fernández-Lebrero A, Contador J, Padovani A, Monane M, Verghese PB, Braunstein JB, Kern S, Blennow K, Ashton NJ, Suárez-Calvet M, Hansson O

Citation: Palmqvist S, Warmenhoven N, Anastasi F, et al. Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform. Nature medicine. 2025;31(6):2036-2043. doi:10.1038/s41591-025-03622-w

Article Links: PubMed · Journal / DOI · Free Full Text (PMC)

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