Resmetirom Achieves Dual Histologic Endpoints in NASH Fibrosis

MAESTRO-NASH provides the first Phase 3 histologic evidence supporting an oral thyroid hormone receptor-beta agonist as pharmacotherapy for biopsy-confirmed nonalcoholic steatohepatitis with fibrosis, a condition previously without any approved drug.

resmetiromRezdiffrathyroid hormone receptor-beta agonistNASHMASHnonalcoholic steatohepatitisliver fibrosishepatologyPhase 3 RCTLDL cholesterolMAESTRO-NASH Gastroenterology / Hepatology

Background Information

Resmetirom could be a breakthrough treatment for NASH with liver fibrosis.

Nonalcoholic steatohepatitis (NASH) is a serious liver condition with no approved treatments, highlighting the need for effective therapies. Resmetirom significantly improved NASH resolution and liver fibrosis in 25.9% to 29.9% of patients compared to 9.7% with placebo. This study indicates resmetirom may be a promising treatment for NASH, warranting further investigation in the clinical setting. Resmetirom shows promise in resolving NASH and improving liver fibrosis.

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Authors: Harrison SA, Bedossa P, Guy CD, Schattenberg JM, Loomba R, Taub R, Labriola D, Moussa SE, Neff GW, Rinella ME, Anstee QM, Abdelmalek MF, Younossi Z, Baum SJ, Francque S, Charlton MR, Newsome PN, Lanthier N, Schiefke I, Mangia A, Pericàs JM, Patil R, Sanyal AJ, Noureddin M, Bansal MB, Alkhouri N, Castera L, Rudraraju M, Ratziu V, MAESTRO-NASH Investigators

Citation: Harrison SA, Bedossa P, Guy CD, et al. A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis. The New England journal of medicine. 2024;390(6):497-509. doi:10.1056/NEJMoa2309000

Article Links: PubMed · Journal / DOI

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