Fixed-dose 4PCC protocol matches weight-based warfarin reversal at lower cost

This multicenter before-and-after study supports a tiered fixed-dose four-factor prothrombin complex concentrate (4PCC) strategy that reduces drug cost without measurably compromising international normalized ratio (INR) reversal.

four-factor prothrombin complex concentrate4PCCKcentrawarfarinINR reversalanticoagulationintracranial hemorrhagecost analysisbefore-and-after studyemergency medicine Anticoagulation

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Authors: Dietrich SK, Mixon M, Holowatyj M, Werth JC, Delgado SA, Mascolo NE, Meister ER, Zoucha SM, Trujillo TC

Citation: Dietrich SK, Mixon M, Holowatyj M, et al. Multi-centered evaluation of a novel fixed-dose four-factor prothrombin complex concentrate protocol for warfarin reversal. The American journal of emergency medicine. 2020;38(10):2096-2100. doi:10.1016/j.ajem.2020.06.017

Article Links: PubMed · Journal / DOI

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